Periodontitis: 2 grapefruits per day for 2 weeks were consumed in a trial evaluating effects on vitamin C status of patients with periodontitis. In one cohort of women, 2 to 4 servings per week or 5 or more servings per week of grapefruit (1 serving of grapefruit was one-half of a grapefruit) also reduced risk. In a trial of healthy postmenopausal women, 340 mL/day (providing 201 mg/day of naringenin) of grapefruit juice was administered for 6 months to evaluate effects on arterial stiffness.ĭiabetes risk: Pooled results from 3 prospective longitudinal cohort studies (N=187,382 3,464,641 person-years of follow-up) reported consumption of 2 to 4 servings per week of grapefruit to reduce the risk of type 2 diabetes. Fresh grapefruit, grapefruit juice, and grapefruit capsules for 6 or 12 weeks, with naringin doses of the formulations ranging from 81 to 142 mg/day, have been used in randomized controlled trials evaluating effects on cardiovascular risk factors in obese adults. Quality clinical trials upon which to base therapeutic dosing recommendations for grapefruit are limited.Ĭardiovascular risk factors: 1 grapefruit daily for 30 days has been used in a clinical trial to improve lipid profiles. Consumption of whole grapefruit has been shown in several analyses to provide improved benefits compared to the juice. Antimicrobial effects have been reported. Some trials also demonstrate reductions in body fat and waist circumference but data regarding use for weight loss are equivocal. Limited data suggest potential benefit for certain patient populations in reducing the risk of renal stones and type 2 diabetes, as well as some cardiovascular risk factors (including improvement in systolic blood pressure, high-density lipoprotein cholesterol, and arterial stiffness). High-quality clinical trials are lacking to support therapeutic applications of grapefruit and grapefruit juice. Also, your medicine container may have a sticker, warning of potential grapefruit interactions.ĭrug interactions are one of the reasons it’s important to tell your doctor and pharmacist of any vitamins, herbal or food supplements you are taking.Scientific Name(s): Citrus paradisi Macfad. This can be found in the medicines packet, or you can search for your medicine’s CMI online here. This should also be stated in the Consumer Medicines Information leaflet for your medicine. Your pharmacist or doctor will be able to advise you whether grapefruit or grapefruit juice will interact with your medicine. How do I know if grapefruit juice will interact with my medicine? Sildenafil ( Viagra) used for erectile dysfunction.Calcium channel blockers, such as felodipine (e.g.Telfast) – in this case blood levels of fexofenadine go down and it becomes less effective. Some antihistamines, such as fexofenadine (e.g.Here are some common medicines that may interact with grapefruit. Lipitor) – the common lipid-lowering statin drug – is one of them. Research has shown that more than 85 medicines can interact with grapefruit, with 43 of them having potentially serious or deadly consequences. Common medicines that grapefruit juice interacts with Seville (or bitter) orange juice and limes may also cause the same effects as grapefruit. Consuming it regularly will make the chance of significant interactions more likely. The effect of grapefruit juice on some medicines can last for over 24 hours. It can happen even when the grapefruit is consumed at a different time from the medicine. Just one glass of grapefruit juice or one serve of grapefruit is all it takes to interfere with your medicine.
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